K9 Advantix II vs Frontline Plus

As a pet owner, we are responsible for their wellbeing and one of the most common problems when you have a pet, especially canine friends, is the flea and ticks that can invest on their skin and furs. But, worry not because there are many solutions out there to handle the problems such as with the reliable and popular K9 Advantix II Vs Frontline Plus. These solutions are very effective and affordable as well but, here is some information you may want to know first regarding the products.

In this article, we are going to give you information about:

  • How to Keep the House and Pet Safe from Insects
  • What are K9 Advantix II and Frontline Plus
  • How are the Package of K9 Advantix II and Frontline Plus
  • What are the Active Ingredients of K9 Advantix II and Frontline Plus
  • How K9 Advantix II and Frontline Plus Work
  • How to Apply K9 Advantix II and Frontline Plus
  • K9 Advantix II Vs Frontline Plus

Keeping Flea and Ticks Away

Dogs are very active animals, they love to play and love open space which is why many of us are looking for a house with a wide yard so our canine friend can enjoy their life being as playful as they want. However, there is another problem besides how to calm them down to not bother the neighbors and it is about those small insects that often invest in your dog’s skin and furs. They are natural parasites that not only cause discomfort but also skin problems if not treated quickly. Read also: LiftMaster 877MAX vs 877LM.

For canine owners, here are some tips to make sure our dogs and our house are free or at least have lower risk of getting invested by these insects. They may take time and effort to do but will be worth it rather than having to see our pets have skin conditions.

Keeping the Yard Safe

For those living in a house with enough open space to have a barbeque party and playing catch with your dog, keeping them clean is the key. Yard with long grass needs to be trimmed short because it will prevent those insects from coming into your property as they have less to no place to hide in the first place. If you often feed a neighbor’s dog or cats outside, make sure to clean the bowl and take it inside to prevent critters and wild animals from coming and spreading the insects.

Trim the trees and high shrubs that may allow wild animals to reach your attic and seal the opening on garages, sheds, or under the decks that small animals can crawl into. If you want to have a green yard, make sure to plant trees or shrubs far from the house and from each other as well as keep them in an area with frequent wind and sunlight. 

Apply Prevention

When the warm months are approaching, usually starting from March in the United States, almost every pet owner, especially dog and outdoor cats, are concerned about their fur friends. For prevention, we can put flea and tick treatments on them. For example brush or comb their furs when getting home before entering the house to reduce the amount they may carry. This is even more important when your pets have long hair as it is easier to hide inside so do consider shaving their furs when nearing summer.

Keeping the House Clean

Insects come from the outside of the house so having them inside doesn’t mean that our house is dirty because they are small and can easily enter the house without getting noticed but, to make sure they have less space to invest, it is best to always keep the house clean and paying attention to certain areas which looks like an ideal hiding place for pest such as the carpet or rug.

About K9 Advantix II and Frontline Plus

If you have done these steps routinely but still find your dogs or pets scratching their body often and seem uncomfortable or you found the insects on their fur, it is the time to step up our game and it is by using flea or tick solutions. They are similar to those used to clean human hair from flea infections but may have different ingredients. The options are also not lacking at all and chances are you have seen some while shopping.

Flea treatment is many pet owners’ savior when it is nearing summer as their pets may want to be more active outside and the weather is great as well out there that you may also want to spend some time playing around with them. This is also an ideal time for fleas and ticks to invest in your pet’s fur as they roll over the grass and play with other pets which may already be infected. To help pet owners be more at ease, we can rely on these solutions.

If you are here then it means you have a canine friend and among those many flea and tick treatment or prevention solutions for dogs, K9 Advantix II and Frontline Plus are two good options to consider. Both of them are equally popular and many pet owners have proven their efficacy to keep their dogs free from these pests. However, since they are made by different companies, there must be some differences as well that may affect your decision.

Both of them are very much similar to each other and in general will be able to keep your pet safe during the flea and tick season as they can repel and kill the insects when exposed to the active ingredients. One factor that is very important to note with both K9 Advantix II and Frontline Plus is you should keep your cats (if any) from the dog as the solution is drying since it is highly toxic if ingested by our felines.

K9 Advantix II and Frontline Plus Package and Dosage

These solutions are topical medication which is designed to be applied directly into your dog’s skin so instead of coming in a shape of collar that often took longer to start working, these two will be active and killing those pests as fast as during the first 12 hours. They come in liquid or thick cream which is packed inside a small bottle in which they have similar mechanisms but different design. Each packet usually has more than one tube; each for one application.

The first step you have to do when looking for a flea and tick solution for the dog is what the solution is made for because the dosage depends on their weight. The Advantix II is made for dogs that are heavier than 22 but weighing less than 55 lbs. But, if you have a large breed, there is another version made for dogs heavier than 55 lbs. as well. On the other hand the Frontline Plus is made for dogs that are weighing between 45 and 88 lbs. 

K9 Advantix II and Frontline Plus Ingredients

The second step to find the best flea and tick solution for your dogs is checking their ingredients. Not only because some of them can be harmful for other animals you may have in the house, it also tells you what the solution is dealing with. Starting with Advantix II, this medicine is made with Imidacloprid, Permethrin, and Pyriproxyfen while on the other hand Frontline Plus is made with Fipronil and S-Methoprene as the active ingredients. The inert ingredients are either preservative or to make the solution mixed well and easy to apply.

K9 Advantix II and Frontline Plus Mechanism 

Imidacloprid is a pesticide and it works by interfering with the transmission of nerve impulses in insects by binding irreversibly to specific insects’ nicotinic acetylcholine receptors and in short killing the pests in its all live stages. Permethrin acts as stomach poison when it gets ingested by insects or as a contact poison through direct contact and it overexcites the nervous system of the insects which eventually causes them to die. It kills fleas, ticks, cockroaches, flies, and mosquitos.

Pyriproxyfen on the other hand is a growth regulator so it mimics the natural insect hormone and in short prevents the insect from growing into adults while also disturbing egg-laying and egg-hatch to prevent them from multiplying. Moving to Frontline Plus Fipronil, this one works by disrupting the normal function of the central nervous system in insects and killing the adult as they come in contact with the insecticide. S-methoprene itself has the same effects as Pyriproxyfen or as a growth regulator.

Applying K9 Advantix II and Frontline Plus

The last part we want to mention here is how to apply the solution but both K9 Advantix II and Frontline Plus are the same as they are equally a topical treatment. Open the tube packaging and split the fur on the back of your dog by making a line with your finger or with a comb. Apply the solution directly to the skin and not to the fur as it needs to spread through their skin to be effective. During the first 24 hour make sure to prevent your cat from getting near the dog.

K9 Advantix II vs Frontline Plus

These flea and tick solutions are equally effective as they are using effective ingredients as well. They will be able to kill adults and eggs or ticks or fleas to prevent further investing. The difference is Advantix II has additional insecticide which is used to poison the pests and overall making the solution even more reliable. Performance wise they should be similar to each other when applied properly.

- Once a month topical flea treatment for dogs
- Kills 98 to 100 percent of fleas within 12 hours
- Safe for dogs 7 weeks and older and weighing 21 55 pounds
- Water resistant; includes 6 applications for 6 months of protection


All in all you can go with either of them depending on which fits your dog’s dosage the most. They can be used for medium sized do while Frontline Plus can be used in larger breeds as well. Personally we prefer Advantix II because it seems to be more effective both in killing and repelling the insects.